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  • 产品名称：anti-MHCClassIIRT-1Bantibody(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-MHCClassIIRT-1Bantibody(FITC)
详情介绍：
Immunogen Rat thymocyte membrane glycoprotein. Spleen cells from immunised BALB/C mice were fused with cells fo the mouse NS1 myeloma cell line.
Clone OX-6
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Rat and Mouse.
Purification Affinity Chromatography on Protein G.
Alternative Name MHC Class II RT1B
Background The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In rats, this complex is referred to as the RT1 region. In mice, this complex is referred to as the H2 region.Synonyms: HLA Class II, MHC Class 2 RT1B
Application Notes Flow cytometry: Neat - 1/10, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
image for anti-MHC Class II RT-1B antibody (FITC) (ABIN118331) Staining of rat spleen cells with Mouse anti Rat RT1B (Class II Monomorphic): FITC (A...
Background publications Burrows, Bebo, Adlard, Vandenbark, Offner: "Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 5987-96, 1998 (PubMed).

McKechnie, Gürr, Braun: "Immunization with the cross-reactive antigens Ov39 from Onchocerca volvulus and hr44 from human retinal tissue induces ocular pathology and activates retinal microglia." in: The Journal of infectious diseases, Vol. 176, Issue 5, pp. 1334-43, 1997 (PubMed).

Whiteland, Nicholls, Shimeld, Easty, Williams, Hill: "Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 43, Issue 3, pp. 313-20, 1995 (PubMed).

Charteris, Lightman: "In vivo lymphokine production in experimental autoimmune uveoretinitis." in: Immunology, Vol. 78, Issue 3, pp. 387-92, 1993 (PubMed).

Male, Pryce, Butcher: "Serological evidence for a defect in RT1.B (I-A) expression by the BDIX rat strain." in: Journal of immunogenetics, Vol. 14, Issue 6, pp. 301-12, 1988 (PubMed).

Fernandez, Weeks: "Genetic monitoring of inbred strains of mice using monoclonal antibodies to major histocompatibility haplotypes and lymphocyte alloantigens." in: Laboratory animals, Vol. 20, Issue 4, pp. 293-7, 1986 (PubMed).

McMaster, Williams: "Identification of Ia glycoproteins in rat thymus and purification from rat spleen." in: European journal of immunology, Vol. 9, Issue 6, pp. 426-33, 1980 (PubMed).