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  • 产品名称：anti-CD14antibody(CD14Molecule)(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD14antibody(CD14Molecule)(PE)
详情介绍：
Immunogen Recombinant mouse CD14
Clone BiG53
Isotype IgG1
Characteristics Synonyms: Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein
Purification Purified IgG prepared by affinity chromatography on Protein G
Alternative Name CD14 (CD14 Antibody Abstract)
Background CD14 is a 55kD a glycophosphoinositol-linked cell surface protein that also exists in a soluble form. Expression of CD14 is restricted to the myeloid lineage and is predominantly expressed on peripheral blood monocytes, weakly expressed on granulocytes and absent on myeloid progenitors. The CD14 Molecule acts as a pattern recognition receptor, which binds lipopolysaccharide (LPS) and other microbial products such as lipoteichoic acid, lipoproteins and peptidoglycan. Binding of LPS to CD14 mediates the innate immune response to LPS and requires the Toll-like receptor-4 (TLR4)/MD-2 complex for effective signalling.Synonyms: Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein
UniProt P10810
Research Area Stem Cells, Innate Immunity, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells, Apoptosis/Necrosis, Immunology, Inflammation
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
Application Notes Flow Cytometry: Use 10 μL of neat antibody to label 1x10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1 mL distilled water
Buffer PBS pH 7.4 containing 0.09 % Sodium Azide and 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody at 2-8 °C. DO NOT FREEZE!
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CD14 antibody (CD14 Molecule) (PE) (ABIN317123) anti-CD14 Molecule (CD14) antibody (PE)
Background publications Baumann, Aspalter, Sharif, Pichlmair, Blüml, Grebien, Bruckner, Pasierbek, Aumayr, Planyavsky, Bennett, Colinge, Knapp, Superti-Furga: "CD14 is a coreceptor of Toll-like receptors 7 and 9." in: The Journal of experimental medicine, Vol. 207, Issue 12, pp. 2689-701, 2010 (PubMed).