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  • 产品名称：anti-BCL3antibody(B-CellCLL/lymphoma3)(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-BCL3antibody(B-CellCLL/lymphoma3)(PE)
详情介绍：
Immunogen Recombinant Bcl-3-6-histidine tag from Armenian Hamster. Fusion Partner: SP2/0 myeloma.
Clone Ham150-3-5
Isotype IgG1
Specificity Recognizes B-cell Leukemia/lymphoma 3
Cross-Reactivity (Details) Species reactivity (tested):Human and Mouse.
Purification Protein G Affinity Chromatography.
Alternative Name Bcl-3 (BCL3 Antibody Abstract)
Background B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin. The Mouse Bcl-3 coding region exhibits 80 % homology with Human Bcl-3 which is associated with human B-cell chronic lymphocytic leukemias (CLLs). Bcl-3 is detected in various tissues such as spleen and other lymphoid organs.Synonyms: B-cell lymphoma 3-encoded protein, BCL3, BCL4, D19S37
Gene ID 602
NCBI Accession NP_005169
UniProt P20749
Research Area Cancer
Pathways NF-kappaB Signaling, Maintenance of Protein Location, Protein targeting to Nucleus
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE! Avoid prolonged exposure to light.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Mitchell, Hildeman, Kedl, Teague, Schaefer, White, Zhu, Kappler, Marrack: "Immunological adjuvants promote activated T cell survival via induction of Bcl-3." in: Nature immunology, Vol. 2, Issue 5, pp. 397-402, 2001 (PubMed).

Watanabe, Iwamura, Shinoda, Fujita: "Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-kappaB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation." in: The EMBO journal, Vol. 16, Issue 12, pp. 3609-20, 1997 (PubMed).