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  • 产品名称：anti-CD8antibody(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD8antibody(FITC)
详情介绍：
Immunogen Murine thymocytes
Clone YTS169-4
Isotype IgG2b
Specificity Antibody CL007 reacts with a protein of approximately 30 kDa found on mouse thymocytes and mouse cytotoxic/ suppressor T cells. It does not bind to mouse helper/inducer T cells. It binds to T lymphocytes from all mouse strains regardless of phenotypic expression (i.e. reacts with T lymphocytes from mouse strains expressing the Ly 2.1 or Ly 2.2 phenotype). It can be used to investigate the role of T cells in models for infectious disease, autoimmunity, transplantation tolerance and fundamental aspects of immunology.
Purification Protein G Chromatography
Background The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2
Gene ID 12525
NCBI Accession NP_001074579
UniProt P01731
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Mueller, Davies, Krahl, Sarvetnick: "IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 4, pp. 1599-603, 1997 (PubMed).

Stevenson, Freeman, Bangham, Hawke: "Virus dissemination through the brain parenchyma without immunologic control." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 4, pp. 1876-84, 1997 (PubMed).

Cobbold, Jayasuriya, Nash, Prospero, Waldmann: "Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo." in: Nature, Vol. 312, Issue 5994, pp. 548-51, 1985 (PubMed).

Galfrè, Milstein, Wright: "Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG." in: Nature, Vol. 277, Issue 5692, pp. 131-3, 1979 (PubMed).