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  • 产品名称:anti-CD2antibody(CD2Molecule)(FITC)

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简单介绍:
anti-CD2antibody(CD2Molecule)(FITC)
详情介绍:
Clone 01-12-15
Isotype IgG1
Specificity This antibody is specific to CD2/LFA-2 (Mr 45-58 kDa)
Characteristics Synonyms: T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, SRBC, T-cellsurface antigen CD2, T-cell surface antigen T11/Leu-5
Alternative Name CD2 (CD2 Antibody Abstract)
Background CD2, also known as leukocyte function-associated antigen-2 (LFA-2), is a member of the immunoglobulin superfamily of cell adhesion molecules. (Ref.1) It is expressed on the surface of >95 % of thymocytes, and essentially all B cells, T cells and NK cells. (Ref.1-3) In the mouse, CD2 is the receptor for CD48. (Ref.4) CD2 is thought to play a major role in mediating T-cell adhesion, T-cell recognition/activation, T-cell signaling and intrathymic differentiation. (Ref.5-10)Synonyms: Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, SRBC, T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5
Gene ID 12481
UniProt P08920
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry < / = 1 μg/10^6 cells. (Ref.1-3)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CD2 antibody (CD2 Molecule)  (FITC) (ABIN356209) anti-CD2 Molecule (CD2) antibody (FITC)
Background publications Kato, Koyanagi, Okada, Takanashi, Wong, Williams, Okumura, Yagita: "CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1241-9, 1992 (PubMed).

Altevogt, Kohl, Von Hoegen, Lang, Schirrmacher: "Antibody 12-15 cross-reacts with mouse Fc gamma receptors and CD2: study of thymus expression, genetic polymorphism and biosynthesis of the CD2 protein." in: European journal of immunology, Vol. 19, Issue 2, pp. 341-6, 1989 (PubMed).

Altevogt, Michaelis, Kyewski: "Identical forms of the CD2 antigen expressed by mouse T and B lymphocytes." in: European journal of immunology, Vol. 19, Issue 8, pp. 1509-12, 1989 (PubMed).

Bierer, Peterson, Barbosa, Seed, Burakoff: "Expression of the T-cell surface molecule CD2 and an epitope-loss CD2 mutant to define the role of lymphocyte function-associated antigen 3 (LFA-3) in T-cell activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 4, pp. 1194-8, 1988 (PubMed).

Shaw, Luce: "The lymphocyte function-associated antigen (LFA)-1 and CD2/LFA-3 pathways of antigen-independent human T cell adhesion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 139, Issue 4, pp. 1037-45, 1987 (PubMed).

Alcover, Ramarli, Richardson, Chang, Reinherz: "Functional and molecular aspects of human T lymphocyte activation via T3-Ti and T11 pathways." in: Immunological reviews, Vol. 95, pp. 5-36, 1987 (PubMed).

Linch, Wallace, OFlynn: "Signal transduction in human T lymphocytes." in: Immunological reviews, Vol. 95, pp. 137-59, 1987 (PubMed).

Selvaraj, Plunkett, Dustin, Sanders, Shaw, Springer: "The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3." in: Nature, Vol. 326, Issue 6111, pp. 400-3, 1987 (PubMed).

Shaw, Luce, Quinones, Gress, Springer, Sanders: "Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones." in: Nature, Vol. 323, Issue 6085, pp. 262-4, 1986 (PubMed).