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  • 产品名称：anti-CD7antibody(CD7)(Biotin)

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简单介绍：
anti-CD7antibody(CD7)(Biotin)
详情介绍：
Immunogen Normal human peripheral blood lymphocytes. Spleen cells from immunised BALB/c mice were fused with cells of the X63.653 mouse myeloma cell line.
Clone LT7
Isotype IgG2a
Specificity This antibody is a single chain cell surface glycoprotein of 40 kDa, expressed by T cells, NK cells and thymocytes. CD7 is also expressed by tumour cells in some cases of acute myeloid leukaemia.
Purification Affinity chromatography on Protein A
Alternative Name CD7 (CD7 Antibody Abstract)
Background CD7 is a 40 kDa transmembrane, single-chain glycoprotein, which is a member of the immunoglobulin superfamily. CD7 is expressed by the majority of thymocytes and mature T cells, NK cells and pre-B cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. The function of CD7 is not yet known although cross-linking of CD7 with antibodies induces a T cell transmembrane calcium flux and CD7 expression is induced by ionomycin. The CD7 Molecule has been reported to be the receptor for the IgM-Fc portion (FcR mu) on the surface of T cells.Synonyms: GP40, Leu-9, T-cell leukemia antigen, TP41
Gene ID 924
NCBI Accession NP_006128
UniProt P09564
Research Area Immunology, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways Cell-Cell Junction Organization
Application Notes Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % Bovine Serum Albumin as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Haynes, Denning, Singer, Kurtzberg: "Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development." in: Immunology today, Vol. 10, Issue 3, pp. 87-91, 1989 (PubMed).

Aruffo, Seed: "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system." in: The EMBO journal, Vol. 6, Issue 11, pp. 3313-6, 1988 (PubMed).