产品详情
所在位置: 首页> 产品目录> 一抗>
查看大图

  • 产品名称：anti-CD45antibody(ProteintyrosinePhosphatase,ReceptorType,C)(PE)

  • 产品型号：
  • 产品厂商：Acris-antibodies
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
anti-CD45antibody(ProteintyrosinePhosphatase,ReceptorType,C)(PE)
详情介绍：
Immunogen Cloned mouse Th2 cell lines. (Ref. 1)
Clone C363-16A
Isotype IgG2a
Specificity CD45RB
Characteristics Synonyms: Leukocyte common antigen, L-CA, PTPRC, T200, CD45RB, CD45RO, CD45RA, CD45R
Alternative Name CD45 / LCA (PTPRC Antibody Abstract)
Background CD45RB is an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, naive T cells, thymocytes, weakly on macrophages, and dendritic cells. It plays a critical role in TCR and BCR signaling. As T cells become activated and progress from naive to memory cells, CD45RB expression is downregulated. Additionally, functionally distinct CD4 T cell subsets, which secrete differing cytokine profiles, can be separated by CD45RB intensity. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4 and Thy-1. Distribution: Peripheral B cells, naive T cells, most thymocytes, low density on macrophages and dendritic cells. Function: Phosphatase, T cell development and activation Structure: Phosphatase receptor (CD45 gene exon 5), 220 kDSynonyms: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
UniProt P06800
Pathways TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events
Application Notes Flow Cytometry. < / = 0.2 μg/10^6 cells. (Ref.1-3)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative and a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CD45 antibody (Protein tyrosine Phosphatase, Receptor Type, C) (PE) (ABIN370966) anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody (PE)
Background publications Hathcock, Laszlo, Dickler, Sharrow, Johnson, Trowbridge, Hodes: "Expression of variable exon A-, B-, and C-specific CD45 determinants on peripheral and thymic T cell populations." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 1, pp. 19-28, 1992 (PubMed).

Bottomly, Luqman, Greenbaum, Carding, West, Pasqualini, Murphy: "A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines." in: European journal of immunology, Vol. 19, Issue 4, pp. 617-23, 1989 (PubMed).

Johnson, Greenbaum, Bottomly, Trowbridge: "Identification of the alternatively spliced exons of murine CD45 (T200) required for reactivity with B220 and other T200-restricted antibodies." in: The Journal of experimental medicine, Vol. 169, Issue 3, pp. 1179-84, 1989 (PubMed).

Birkeland, Metlay, Sanders, Fernandez-Botran, Vitetta, Steinman, Puré: "Epitopes on CD45R [T200] molecules define differentiation antigens on murine B and T lymphocytes." in: The Journal of molecular and cellular immunology : JMCI, Vol. 4, Issue 2, pp. 71-85, 1989 (PubMed).