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  • 产品名称：anti-CD45antibody(ProteintyrosinePhosphatase,ReceptorType,C)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD45antibody(ProteintyrosinePhosphatase,ReceptorType,C)(FITC)
详情介绍：
Immunogen Human T Lymphocytes. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Clone F8-11-13
Isotype IgG1
Specificity This antibody recognises the human CD45RA cell surface antigen. Clone F8-11-13 reacts with the high molecular weight form of the leucocyte common antigen (LCA) expressed by B lymphocytes and a subset of T lymphocytes.
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Alternative Name CD45 / LCA (PTPRC Antibody Abstract)
Background CD45 is a complex molecule existing in a number of isoforms. Antibodies recognising a common epitope on all of these isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.Synonyms: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
Gene ID 5788
NCBI Accession NP_002829
UniProt P08575
Pathways TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted at -20 °C.
Background publications Franitza, Kollet, Brill, Vaday, Petit, Lapidot, Alon, Lider: "TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules." in: European journal of immunology, Vol. 32, Issue 1, pp. 193-202, 2001 (PubMed).

OGrady, Stewart, Lowrey, Howie, Krajewski: "CD40 expression in Hodgkin's disease." in: The American journal of pathology, Vol. 144, Issue 1, pp. 21-6, 1994 (PubMed).

Dalchau, Fabre et al.: "Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the ..." in: The Journal of experimental medicine, Vol. 153, Issue 4, pp. 753-65, 1981 (PubMed).