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  • 产品名称：anti-VCAM1antibody(VascularCellAdhesionMolecule1)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-VCAM1antibody(VascularCellAdhesionMolecule1)(FITC)
详情介绍：
Clone 1-G11B1
Isotype IgG1
Specificity This antibody recognises Human VCAM-1, a 110 kDa molecule whose ligand is VLA-4. The antigen is expressed on activated endothelial cells and some tissue macrophages, bone marrow fibroblasts and myoblasts.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography on Protein G.
Alternative Name CD106 / VCAM1 (VCAM1 Antibody Abstract)
Background VCAM1 is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells.Synonyms: INCAM-100, L1CAM, V-CAM 1, VCAM-1, Vascular cell adhesion protein 1
Gene ID 7412
NCBI Accession NP_001069
UniProt P19320
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Carbohydrate Homeostasis
Application Notes Flow Cytometry: use 10 μL of neat-1/10 diluted antibody to label 10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 0.1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Peterson, Vlasova, Di Ciano-Oliveira, Downey, Cybulsky, Kapus, Waddell: "Monocyte-induced endothelial calcium signaling mediates early xenogeneic endothelial activation." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 5, Issue 2, pp. 237-47, 2005 (PubMed).

Rosenman, Shrikant, Dubb, Benveniste, Ransohoff: "Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 4, pp. 1888-99, 1995 (PubMed).

Thornhill, Wellicome, Mahiouz, Lanchbury, Kyan-Aung, Haskard et al.: "Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 2, pp. 592-8, 1991 (PubMed).