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  • 产品名称：anti-CD40antibody(CD40Molecule,TNFReceptorSuperfamilyMember5)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD40antibody(CD40Molecule,TNFReceptorSuperfamilyMember5)(FITC)
详情介绍：
Immunogen Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Clone LOB7-6
Isotype IgG2a
Specificity This antibody recognises the CD40 cell surface antigen.
Purification Affinity chromatography on Protein A
Alternative Name CD40 (CD40 Antibody Abstract)
Background CD40 is a 48kD glycoprotein expressed by B lymphocytes and weakly by some monocytes. CD40 is involved in the process of B cell selection in germinal centres, and is vital in T cell-B cell interactions.Synonyms: B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, TNFRSF5, Tumor necrosis factor receptor superfamily member 5
Gene ID 958
NCBI Accession NP_001241
UniProt P25942
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells, Apoptosis/Necrosis, Inflammation, Cancer
Pathways NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Application Notes Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Kirsch, Zeyda, Stuhlmeier, Grisar, Smolen, Watschinger, Stulnig, Hörl, Zlabinger, Säemann: "The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function." in: Arthritis research & therapy, Vol. 7, Issue 3, pp. R694-703, 2005 (PubMed).

Quadbeck, Eckstein, Tews, Walz, Hoermann, Mann, Gieseler: "Maturation of thyroidal dendritic cells in Graves' disease." in: Scandinavian journal of immunology, Vol. 55, Issue 6, pp. 612-20, 2002 (PubMed).