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  • 产品名称：anti-FcFragmentofIgG,LowAffinityIIa,Receptor(CD32)(FCGR2A)antibody(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-FcFragmentofIgG,LowAffinityIIa,Receptor(CD32)(FCGR2A)antibody(PE)
详情介绍：
Immunogen K562 cell line. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Clone AT10
Isotype IgG1
Specificity This antibody recognizes the Human CD32 antigen. Clone AT10 blocks the binding of IgG to Fc gamma R11 (See Larsson, M. et al. for details). SM1092LE is recommended for this purpose.
Purification Affinity chromatography on Protein A
Alternative Name CD32 / FcRII-A (FCGR2A Antibody Abstract)
Background CD32 is a 40kD glycoprotein that acts as a low affinity receptor for IgG (also known as Fc gamma RII). The antigen mediates several functions including endocytosis, activation of secretion, cytotoxicity and immunomodulation.CD32 is expressed by B cells, monocytes, granulocytes and platelets.Synonyms: CDw32, FCG2, FCGR2A, FCGR2A1, Fc-gamma RII-a, Fc-gamma-RIIa, IGFR2, IgG Fc receptor II, Low affinity immunoglobulin gamma Fc region receptor II
Gene ID 2212
NCBI Accession NP_001129691
UniProt P12318
Application Notes Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1.0 mL distilled water.
Buffer PBS, 0.09 % Sodium Azide, 1 % BSA, 5 % sucrose
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Background publications Lilliehöök, Johannisson, Håkansson: "Expression of adhesion and Fcgamma-receptors on canine blood eosinophils and neutrophils studied by anti-human monoclonal antibodies." in: Veterinary immunology and immunopathology, Vol. 61, Issue 2-4, pp. 181-93, 1998 (PubMed).

Larsson, Berge, Johansson, Forsum: "Human dendritic cells handling of binding, uptake and degradation of free and IgG-immune complexed dinitrophenylated human serum albumin in vitro." in: Immunology, Vol. 90, Issue 1, pp. 138-46, 1997 (PubMed).

Van Den Herik-Oudijk, Westerdaal, Henriquez, Capel, Van De Winkel: "Functional analysis of human Fc gamma RII (CD32) isoforms expressed in B lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 2, pp. 574-85, 1994 (PubMed).

Greenman, Tutt, George, Pulford, Stevenson, Glennie: "Characterization of a new monoclonal anti-Fc gamma RII antibody, AT10, and its incorporation into a bispecific F(ab')2 derivative for recruitment of cytotoxic effectors." in: Molecular immunology, Vol. 28, Issue 11, pp. 1243-54, 1992 (PubMed).