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  • 产品名称：anti-CD48antibody(CD48Molecule)(FITC)

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简单介绍：
anti-CD48antibody(CD48Molecule)(FITC)
详情介绍：
Immunogen Recombinant soluble mouse CD48. Spleen cells from immunised AO Rats immunised were fused with cells from the Rat Y3 myeloma cell line.
Clone OX-78
Isotype IgG2a
Specificity This antibody labels thymocytes, B and T cells and macrophages. CD48 is a ligand for the mouse CD2 cell surface antigen.
Purification Affinity chromatography on Protein G
Alternative Name CD48 (CD48 Antibody Abstract)
Background CD48 is a glycosyl phophatidyl inositol (GPI) anchored cell surface protein also known as Blast1, HuLy m3, BCM1 (in mouse), and OX45 (in rat). CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibrolasts, epithelium and endothelium. CD48 is one of the markers for detecting the defects of GPI anchoring structure on patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2. The CD48 antigen is closely related to the activation antigen, Blast 1.Synonyms: B-lymphocyte activation marker BLAST-1, BCM1, BCM1 surface antigen, BLAST1, Leukocyte antigen MEM-102, MEM-102, TCT.1
Gene ID 12506
NCBI Accession NP_031675
UniProt P18181
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: Use 10 μL of neat antibody to label 10^6 cells. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Handle under aseptic conditions.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Kato, Koyanagi, Okada, Takanashi, Wong, Williams, Okumura, Yagita: "CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1241-9, 1992 (PubMed).