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  • 产品名称：anti-CD79aMolecule,Immunoglobulin-Associatedalpha(CD79A)antibody(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD79aMolecule,Immunoglobulin-Associatedalpha(CD79A)antibody(FITC)
详情介绍：
Immunogen IgM complex isolated from Daudi cells. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Clone ZL7-4
Isotype IgG1
Specificity This antibody reacts with CD79a positive cells by flow cytometry. This clone has been reported to be useful in distinguishing B-CLL from mantle cell lymphoma in flow cytometric assays.
Alternative Name CD79a (CD79A Antibody Abstract)
Background A disulfide-linked heterodimer, consisting of CD79a / mb1 and CD79b / B29 polypeptides, is non-covalently associated with membrane bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling.Synonyms: B-Cell marker, B-cell antigen receptor complex-associated protein alpha-chain, IGA, MB-1 membrane glycoprotein, MB1, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein
Gene ID 973
NCBI Accession NP_001774
UniProt P11912
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: Use 10 μL of neat antibody to label 1x10^6 cells in 100 μL. We recommend incubation times of at least 30 minutes with this antibody.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Bell, Rooney, Bosanquet: "CD79a detected by ZL7.4 separates chronic lymphocytic leukemia from mantle cell lymphoma in the leukemic phase." in: Cytometry, Vol. 38, Issue 3, pp. 102-5, 1999 (PubMed).

Zhang, French, Chan, OKeefe, Cragg, Power, Glennie: "The development of anti-CD79 monoclonal antibodies for treatment of B-cell neoplastic disease." in: Therapeutic immunology, Vol. 2, Issue 4, pp. 191-202, 1997 (PubMed).