产品详情
所在位置: 首页> 产品目录> 一抗>
查看大图

  • 产品名称：anti-TLR4antibody(Toll-LikeReceptor4)(FITC)

  • 产品型号：
  • 产品厂商：BioLeaf
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
anti-TLR4antibody(Toll-LikeReceptor4)(FITC)
详情介绍：
Immunogen Mouse TLR4-MD-2 transfected Ba/F3 cell
Clone UT49
Isotype IgG2b
Specificity This antibody reacts with mouse TLR4 but doesn't react with mouse MD-2 on flow cytometry.
Purification Protein A agarose
Alternative Name CD284 / TLR4 (TLR4 Antibody Abstract)
Background Toll, a Drosophila receptor molecule with extracellular leucine-rich repeat (LRR), has a role in triggering innate defenses against bacteria or fungi. TLR4 (Toll-like receptor 4) is a member of TLR family, which is human homologue of Toll protein. It has extracellular LRR and an intracellular signaling domain, which is similar to the type I IL-1 receptor. TLR4 is expressed in subpopulations of cells including myeloid cells, B-cells, monocytes, and endothelial cells. Recent studies have suggested that TLR4 might act as a receptor for LPS (lipopolysaccharide). TLR4 alone is not capable of sensing and signaling the presence of LPS, but another molecule MD-2, which is physically as sociated with TLR4, is required for LPS recognition through TLR4.Synonyms: Toll-like receptor 4
Gene ID 21898
NCBI Accession NP_067272
UniProt Q9QUK6
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 1 % BSA and 0.09 % NaN3
Storage 4 °C
Storage Comment Store at 2-8 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-TLR4 antibody (Toll-Like Receptor 4) (FITC) (ABIN2853611) anti-Toll-Like Receptor 4 (TLR4) antibody (FITC)
Background publications Tsutsumi-Ishii, Nagaoka: "Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 8, pp. 4226-36, 2003 (PubMed).

Uehara, Sugawara, Watanabe, Echigo, Sato, Yamaguchi, Takada: "Constitutive expression of a bacterial pattern recognition receptor, CD14, in human salivary glands and secretion as a soluble form in saliva." in: Clinical and diagnostic laboratory immunology, Vol. 10, Issue 2, pp. 286-92, 2003 (PubMed).

Fuller, Bayley, Chambers: "Activin A is an essential cofactor for osteoclast induction." in: Biochemical and biophysical research communications, Vol. 268, Issue 1, pp. 2-7, 2000 (PubMed).

Shimazu, Akashi, Ogata, Nagai, Fukudome, Miyake, Kimoto: "MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4." in: The Journal of experimental medicine, Vol. 189, Issue 11, pp. 1777-82, 1999 (PubMed).