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  • 产品名称：anti-C-TypeLectinDomainFamily6,MemberA(CLEC6A)(ExtracellularDomain)antibody(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-C-TypeLectinDomainFamily6,MemberA(CLEC6A)(ExtracellularDomain)antibody(PE)
详情介绍：
Immunogen Dectin-2 (extracellular domain) Fc Fusion protein
Clone D2-11E4
Isotype IgG2a
Specificity This antibody recognises DC-associated C-type lectin-2 (Dectin-2). Clone D2.11E4 does not stain brain microglia or meningeal macrophages.
Purification Affinity chromatography on Protein G
Alternative Name Dectin-2 (CLEC6A Antibody Abstract)
Background Dectin-2 is a type II transmembrane protein that is a member of the C-type lectin superfamily. In mouse, dectin-2 is predominantly expressed on tissue macrophages and some dendritic cells. Significant expression of Dectin-2 has been reported on macrophages in the red pulp and marginal zones of the spleen, kupffer cells in the liver and alveolar macrophages in the lung. Peripheral blood monocytes express low levels of dectin-2 but transient up-regulation of expression has been demonstrated on monocytes at sites of inflammation. The function of dectin-2 has not been fully determined but studies suggest a possible role in immunesurveillance.Synonyms: C-type lectin domain family 6 member A, C-type lectin superfamily member 10, CLEC6A, CLECSF10, DC-associated C-type lectin 2, DECTIN2, Dendritic cell-associated lectin 2
Gene ID 93978
NCBI Accession NP_001007034
UniProt Q6EIG7
Application Notes Flow Cytometry: neat - 1/5, use 10 μL of the suggested working dilution to label 106 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1 mL distilled water.
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody at 2-8 °C. DO NOT FREEZE!
Background publications Taylor, Reid, Heinsbroek, Brown, Gordon, Wong: "Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo." in: European journal of immunology, Vol. 35, Issue 7, pp. 2163-74, 2005 (PubMed).