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  • 产品名称：anti-CD5antibody(CD5Molecule)(FITC)

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简单介绍：
anti-CD5antibody(CD5Molecule)(FITC)
详情介绍：
Immunogen Rat thymocyte glycoproteins. Spleen cells from immunised BALB/c mouse were fused with cells of the NS1 mouse myeloma cell line.
Clone OX-19
Isotype IgG1
Specificity This antibody recognises the CD5 cell surface antigen. OX-19 has been reported as being suitable for use on periodate-lysine paraformaldehyde (PLP) fixed paraffin embedded tissue.
Purification Purified IgG prepared by affinity chromatography on Protein G
Alternative Name CD5 (CD5 Antibody Abstract)
Background CD5 is a 55 kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.Synonyms: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5
Gene ID 54236
NCBI Accession NP_062168
UniProt P51882
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Huitinga, Ruuls, Jung, Van Rooijen, Hartung, Dijkstra: "Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats." in: Clinical and experimental immunology, Vol. 100, Issue 2, pp. 344-51, 1995 (PubMed).

Whiteland, Nicholls, Shimeld, Easty, Williams, Hill: "Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 43, Issue 3, pp. 313-20, 1995 (PubMed).

Dallman, Thomas, Green: "MRC OX-19: a monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses." in: European journal of immunology, Vol. 14, Issue 3, pp. 260-7, 1984 (PubMed).

Dallman, Mason, Webb: "The roles of host and donor cells in the rejection of skin allografts by T cell-deprived rats injected with syngeneic T cells." in: European journal of immunology, Vol. 12, Issue 6, pp. 511-8, 1982 (PubMed).