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  • 产品名称：anti-CD31antibody(Platelet/endothelialCellAdhesionMolecule)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD31antibody(Platelet/endothelialCellAdhesionMolecule)(FITC)
详情介绍：
Immunogen Activated, Lewis rat derived microglial cells. Spleen cells from immunised BALB/c mouse were fused with cells of the mouse SP2 myeloma cell line.
Clone TLD-3A12
Isotype IgG1
Specificity This antibody recognises PECAM-1 (CD31), a type 1 transmembrane protein expressed primarily on endothelial cells, platelets and leucocytes. Clone TLD-3A12 has been shown to partially block the proliferative response of antigen-specific CD4+ T cells to antigen-presenting cells and relevant antigen. (3) We recommend SM272LE for use in functional studies.
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Alternative Name CD31 / PECAM1 (PECAM1 Antibody Abstract)
Background CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed on the surface of endothelial cells, and concentrated at the junction between them. It is also weakly expressed on many peripheral lymphoid cells and platelets. CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas).Synonyms: End °CAM, GPIIA', PECAM-1, Platelet endothelial cell adhesion molecule
Gene ID 29583
NCBI Accession NP_113779
UniProt Q3SWT0
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of Actin Filament Polymerization
Application Notes Flow Cytometry: Use 10 μL of 1/50-1/100 diluted antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS, pH 7.4 containing 1 % BSA as stabilizer and 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Lochhead, McCaffrey, Quigley, Finch, DeMarco, Nametz, Davis: "Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 30, Issue 9, pp. 1625-36, 2010 (PubMed).

Ferreri, Illerhaus, Zucca, Cavalli: "Flows and flaws in primary central nervous system lymphoma." in: Nature reviews. Clinical oncology, Vol. 7, Issue 8, pp. doi:10.1038/nrclinonc.2010.9-c1; author reply doi:10:1038/nrclinonc.2010.9-c2, 2010 (PubMed).

Stevenson, McGlynn, Hodge, McLinden, George, Davies, Shiels: "Isolation, characterization, and differentiation of thy1.1-sorted pancreatic ***** progenitor cell populations." in: Stem cells and development, Vol. 18, Issue 10, pp. 1389-98, 2009 (PubMed).

Thebault, Lhermite, Tilly, Le Texier, Quillard, Heslan, Anegon, Soulillou, Brouard, Charreau, Cuturi, Chiffoleau: "The C-type lectin-like receptor CLEC-1, expressed by myeloid cells and endothelial cells, is up-regulated by immunoregulatory mediators and moderates T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 5, pp. 3099-108, 2009 (PubMed).

Fujimoto, Tobita, Merryman, Guan, Momoi, Stolz, Sacks, Keller, Wagner: "An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial infarction." in: Journal of the American College of Cardiology, Vol. 49, Issue 23, pp. 2292-300, 2007 (PubMed).

Ott, Keller, Knoedler, Götze, Doss, Fischer, Urlbauer, Debus, von Bubnoff, Rudelius, Schömig, Peschel, Oostendorp: "Endothelial-like cells expanded from CD34+ blood cells improve left ventricular function after experimental myocardial infarction." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 19, Issue 8, pp. 992-4, 2005 (PubMed).

Haywood, McWilliams, Pearson, Gill, Ganesan, Wilson, Walsh: "Inflammation and angiogenesis in osteoarthritis." in: Arthritis and rheumatism, Vol. 48, Issue 8, pp. 2173-7, 2003 (PubMed).

Kielian, Hickey: "Proinflammatory cytokine, chemokine, and cellular adhesion molecule expression during the acute phase of experimental brain abscess development." in: The American journal of pathology, Vol. 157, Issue 2, pp. 647-58, 2000 (PubMed).

Graham, Crooke, Monteith, Cooper, Lemonidis, Stecker, Martin, Crooke: "In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration." in: The Journal of pharmacology and experimental therapeutics, Vol. 286, Issue 1, pp. 447-58, 1998 (PubMed).

Williams, Zhao, Ueno, Hickey: "PECAM-1 (CD31) expression in the central nervous system and its role in experimental allergic encephalomyelitis in the rat." in: Journal of neuroscience research, Vol. 45, Issue 6, pp. 747-57, 1997 (PubMed).

Male, Rahman, Linke, Zhao, Hickey: "An interferon-inducible molecule on brain endothelium which controls lymphocyte adhesion mediated by integrins." in: Immunology, Vol. 84, Issue 3, pp. 453-60, 1995 (PubMed).

Flaris, Densmore, Molleston, Hickey et al.: "Characterization of microglia and macrophages in the central nervous system of rats: definition of the differential expression of molecules using standard and novel monoclonal antibodies in normal ..." in: Glia, Vol. 7, Issue 1, pp. 34-40, 1993 (PubMed).