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  • 产品名称：anti-BMP6antibody(BoneMorphogeneticProtein6)(AA1-29)(Biotin)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-BMP6antibody(BoneMorphogeneticProtein6)(AA1-29)(Biotin)
详情介绍：
Immunogen Aminoterminal synthetic peptide 1-29.
Clone Morph-6-1
Isotype IgG1
Specificity This antibody reacts with Bone morphogenic Protein-6 (BMP-6). Antigen specificity of morph-6.1: Pre-incubation of morph-6.1 with amino-terminal peptide 1-29 of BMP-6 inhibits binding of the mAb to tissue sections. Pre-incubation with other amino-terminal synthetic peptides of human BMP-7, BMP-4, BMP-3 and BMP-2 as well as an irrelevant peptide does not inhibit specific tissue staining. Antigen Distribution on Tissue Sections: Positive staining can be observed in embryonic and ***** central nervous system. Rat radial glial cells of the developing central nervous system from E11 to E19. In rat peripheral nerves a selective intracellular immunoreactivity can be found in perinuclear region of most Schwann cells which form the myelin sheath. However, some Schwann cells were negative for morph-6.1. BMP-6 can also be found in a variety of other tissues and cell types, notably keratinizing epithelial cells. Smooth muscle cells, characterized by Desmin positivity, were positively stained in normal tissues and in atherosclerotic plaques. Macrophages (CD68+) and endothelial cells were negative with morph-6.1.
Cross-Reactivity (Details) Species reactivity (tested):Rat, Human (Phylogenetically highly conserved antigen).
Purification Affinity Chromatography.
Alternative Name BMP6 (BMP6 Antibody Abstract)
Background Bone Morphogenetic Proteins (BMP) are members of the TGF beta superfamily of cytokines that affect bone and cartilage formation. Similar to other TGF beta family proteins, BMPs are highly conserved across animal species. BMPs are involved in embryogenesis and morphogenesis of various tissues and organs. BMP6 is an autocrine stimulator of chondrocyte differentiation and has been implicated in the development of embryonic kidney and urinary systems. It is involved in liver growth and differentiation, keratinocyte differentiation, and regulation of neuronal tissue development. BMP6 expression is localized to smooth muscle cells of normal cerebral blood vessels, intimal plaques and atherosclerotically changed blood vessels, further suggesting a role as a regulator of developing tissues. BMP-6 is a member of the TGF-beta superfamily of cytokines regulating homeotic gene expression, embryonic development and neurogenesis.Synonyms: BMP-6, Bone morphogenetic protein 6, VGR, VGR1
Gene ID 25644
NCBI Accession NP_037239
UniProt Q04906
Research Area Stem Cells, Extracellular Matrix, Signaling
Pathways Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process
Application Notes Immunohistochemistry on Frozen Sections: 1-2 μg/mL (1/100-1/200). Immunohistochemistry on Paraffin Sections (Microwave pretreatment for antigen retrievalis recommended). Recommended Dilutions: Rat Brain.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 0.5 mL distilled water.
Concentration 0.2 mg/mL
Buffer PBS, pH 7.2 with 0.09 % Sodium Azide as preservative and 5 mg/mL BSA as stabilizer
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Dilute only prior to immediate use
Storage 4 °C
Storage Comment Store the antibody at 2-8 °C as an undiluted liquid. DO NOT FREEZE! Freezing alkaline phosphatase conjugates will result in a substantial loss of enzymatic activity.