产品详情
所在位置: 首页> 产品目录> 一抗>
查看大图

  • 产品名称：anti-MARCOantibody(MacrophageReceptorwithCollagenousStructure)(PE)

  • 产品型号：
  • 产品厂商：Acris-antibodies
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
anti-MARCOantibody(MacrophageReceptorwithCollagenousStructure)(PE)
详情介绍：
Immunogen CHO cells expressing Mouse MARCO. Remarks: Spleen cells from immunised rats were fused with cells of the mouse SP2/0 myeloma cell line.
Clone ED31
Isotype IgG1
Specificity This antibody recognises the cell surface antigen designated MARCO (Macrophage receptor with collagenous structure). Clone ED31 binds to the C-terminal cysteine rich domain of MARCO, and has been shown to block ligand binding.
Purification Affinity Chromatography on Protein G
Alternative Name MARCO (MARCO Antibody Abstract)
Background MARCO is a member of the class A scavenger receptor family. MARCO is expressed by distinct populations of macrophages in the spleen and lymph nodes, but is rapidly induced on macrophages in other tissues (e.g. Liver Kupffer cells) during infection or LPS treatment.Synonyms: Scavenger Receptor, macrophage receptor with collagenous structure
Gene ID 17167
NCBI Accession NP_034896
UniProt Q60754
Research Area Receptors
Pathways Activation of Innate immune Response
Application Notes Flow Cytometry: The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1 mL distilled water
Buffer PBS containing 1 % BSA, 5 % Sucrose as stabilizers and 0.09 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage RT/4 °C/-20 °C
Storage Comment Lyophilized: Store at 2-8 °C (preferably in a dessicator). Reconstituted: Aliquot and store at -20 °C.
Background publications Devey, Ferenbach, Mohr, Sangster, Bellamy, Hughes, Wigmore: "Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 17, Issue 1, pp. 65-72, 2008 (PubMed).

Beamer, Holian: "Silica suppresses Toll-like receptor ligand-induced dendritic cell activation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 22, Issue 6, pp. 2053-63, 2008 (PubMed).

Dioszeghy, Rosas, Maskrey, Colmont, Topley, Chaitidis, Kühn, Jones, Taylor, ODonnell: "12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 9, pp. 6514-24, 2008 (PubMed).

Hsu, Pratt, Akers, Achilefu, Yokoyama: "Murine cytomegalovirus displays selective infection of cells within hours after systemic administration." in: The Journal of general virology, Vol. 90, Issue Pt 1, pp. 33-43, 2008 (PubMed).

Anthony, Wermeling, Karlsson, Ravetch: "Identification of a receptor required for the anti-inflammatory activity of IVIG." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 50, pp. 19571-8, 2008 (PubMed).

Alarcón, Fuenzalida, Santibáñez, von Bernhardi: "Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid." in: The Journal of biological chemistry, Vol. 280, Issue 34, pp. 30406-15, 2005 (PubMed).

Kang, Kim, Bruening, Pack, Charalambous, Pritsker, Moran, Loeffler, Steinman, Park: "The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 1, pp. 215-20, 2004 (PubMed).

Taylor, Zamze, Stillion, Wong, Gordon, Martinez-Pomares: "Development of a specific system for targeting protein to metallophilic macrophages." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 7, pp. 1963-8, 2004 (PubMed).

Karlsson, Guinamard, Bolland, Sankala, Steinman, Ravetch: "Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone." in: The Journal of experimental medicine, Vol. 198, Issue 2, pp. 333-40, 2003 (PubMed).

Granucci, Petralia, Urbano, Citterio, Di Tota, Santambrogio, Ricciardi-Castagnoli: "The scavenger receptor MARCO mediates cytoskeleton rearrangements in dendritic cells and microglia." in: Blood, Vol. 102, Issue 8, pp. 2940-7, 2003 (PubMed).

van der Laan, Döpp, Haworth, Pikkarainen, Kangas, Elomaa, Dijkstra, Gordon, Tryggvason, Kraal: "Regulation and functional involvement of macrophage scavenger receptor MARCO in clearance of bacteria in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 2, pp. 939-47, 1999 (PubMed).

van der Laan, Kangas, Döpp, Broug-Holub, Elomaa, Tryggvason, Kraal: "Macrophage scavenger receptor MARCO: in vitro and in vivo regulation and involvement in the anti-bacterial host defense." in: Immunology letters, Vol. 57, Issue 1-3, pp. 203-8, 1997 (PubMed).