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  • 产品名称：anti-Uromodulinantibody(UMOD)(HRP)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-Uromodulinantibody(UMOD)(HRP)
详情介绍：
Immunogen Human Tamm-Horsfall protein.
Clone 01-10-32
Isotype IgG2b
Specificity Anti-Human Tamm-Horsfall protein (THP) is a monoclonal antibody which reacts with an epitope of the urinary mucoprotein. This monoclonal antibody has shown good localization to the distal tubule and collecting duct as well as to large deposits of Tamm-Horsfall protein which has clogged peri-pelvic veins. This antibody has been tested against 21 different Human proteins in Solid Phase Radioimmunoassay and has been shown to be specific for Tamm-Horsfall protein only. Results of ELISA show no visible reaction with Human albumin or transferrin. Also no staining of Human tissue other than that noted for kidney sections has been observed.
Cross-Reactivity (Details) Species reactivity (expected):Canine (Dog).
Species reactivity (tested):Human.
Purification Protein G Chromatography.
Background Tamm-Horsfall Protein (THP) is a glycoprotein of approximately 80 kDa containing up to 25 % carbohydrate by weight. It exists as a high molecular weight polymer in urine and approximately 50 mg of the THP are excreted per day by ***** humans. THP is produced by the epithelial cells lining the thick ascending loop of Henle and distal convoluted tubules of the kidney. THP is also the primary constituent of renal tubular casts and THP aggregation has been implicated as a factor in the pathogenesis of acute renal failure by causing tubular obstruction. Antibody to THP is present in the serum of patients with pyelonephritis and reflus uropathy.Synonyms: THP, Tamm-Horsfall urinary glycoprotein
Gene ID 7369
NCBI Accession NP_001008390
UniProt P07911
Research Area Serum/Plasma Proteins
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS containing 50 % Glycerol (v/v)., 4-5 mg/mL BSA
Precaution of Use Avoid exposure of conjugate to Sodium Azide or Thimerosal, as these can inhibit peroxidase activity.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted at (in aliquots) at -20 °C. This product is photosensitive and should be protected from light.
Background publications Nagashima, Mitsuya, Shioi, Noguchi, Kishida, Hamano, Ohgo, Tsuura, Ogawa, Aoki, Yao: "Renal oncocytosis." in: Pathology international, Vol. 55, Issue 4, pp. 210-5, 2005 (PubMed).

Howell, Burchette, Paolini, Geier, Fuller, Sanfilippo: "Characterization of a novel human corneal endothelial antigen." in: Investigative ophthalmology & visual science, Vol. 32, Issue 9, pp. 2473-82, 1991 (PubMed).

Nanus, Ebrahim, Bander, Real, Pfeffer, Shapiro, Albino: "Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression." in: The Journal of experimental medicine, Vol. 169, Issue 3, pp. 953-72, 1989 (PubMed).

Bhagavan, Wenk, Dutta: "Pathways of urinary backflow in obstructive uropathy. Demonstration by pigmented gelatin injection and Tamm-Horsfall uromucoprotein markers." in: Human pathology, Vol. 10, Issue 6, pp. 669-83, 1980 (PubMed).

Zager, Cotran, Hoyer: "Pathologic localization of Tamm-Horsfall protein in interstitial deposits in renal disease." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 38, Issue 1, pp. 52-7, 1978 (PubMed).

McKenzie, McQueen: "Immunofluorescent localization of Tamm-Horsfall mucoprotein in human kidney." in: Journal of clinical pathology, Vol. 22, Issue 3, pp. 334-9, 1970 (PubMed).