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  • 产品名称：anti-ITGALantibody(Integrinalpha-L)(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-ITGALantibody(Integrinalpha-L)(PE)
详情介绍：
Clone DF1524
Isotype IgG2b
Specificity This antibody specifically detects CD11a positive leucocytes. CD11a antigens are expressed on lymphocytes, granulocytes, monocytes and macrophages with increased levels on memory T cells (1,2). Clone DF1524 was clustered at the Leucovyte Typing Workshop IV (5).
Purification Affinity chromatography
Alternative Name CD11a / ITGAL (ITGAL Antibody Abstract)
Background CD11a/CD18 was first described as an accessory molecule in cytotoxic lymphocyte killing. CD11a (Integrin alpha-L) combines with CD18 (Integrin beta-2) to form the integrin LFA-1. LFA-1 mediates adhesion of lymphoid cells to the vascular endothelium in association with its ligands. The avidity of CD11a to its ligands is transiently upregulated on T cells upon activation (3). CD11a has also been shown to bind bacterial lipopolysaccarides (4).Synonyms: CD11 antigen-like family member A, Integrin alpha-L, LFA-1, LFA1, Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocyte function-associated molecule 1 alpha chain
Gene ID 3683
NCBI Accession NP_002200
UniProt P20701
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Activated T Cell Proliferation, Integrin Complex
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. This product is photosensitive and should be protected from light.
Supplier Images
image for anti-ITGAL antibody (Integrin alpha-L) (PE) (ABIN1105773) anti-Integrin alpha-L (ITGAL) antibody (PE)
Background publications Wright, Jong: "Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide." in: The Journal of experimental medicine, Vol. 164, Issue 6, pp. 1876-88, 1987 (PubMed).