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  • 产品名称：anti-SelectinE+CD62eantibody(SelectinE)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-SelectinE+CD62eantibody(SelectinE)(FITC)
详情介绍：
Immunogen LPS-stimulated human endothelial cells
Clone 4D10
Isotype IgG2a
Specificity This antibody detects CD62E / E-Selectin.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Affinity chromatography
Alternative Name CD62E / E-Selectin (SELE Antibody Abstract)
Background CD62E belongs to the selectin family and is thought to mediate rolling of myeloid cells and a subset of memory T cells on activated endothelium. The antigen is a 589 amino acid transmembrane protein. It consists of a C-type lectin-like domain, an epidermal growth factor (EGF)-like domain, six short consensus repeat (SCR) domains, a transmembrane domain and a cytoplasmic tail. CD62E is a counter-receptor for sialyl Lewis X, sialyl Lewis a and CLA (cutaneous lymphocyte antigen). It is involved in adhesion between myeloid cells and activated endothelium, and supports leucocytes rolling. Some skin-associated memory T cells express CLA, and it may be that CD62E is also involved in their homing to cutaneous sites of chronic inflammation. In addition, CD62E may also be involved in tumour metastasis. A soluble form of CD62E has been reported to mediate angiogenesis in pathological disorders.Synonyms: CD62 antigen-like family member E, ELAM1, Endothelial leukocyte adhesion molecule 1, LECAM2, Leukocyte-endothelial cell adhesion molecule 2, SELE
Gene ID 6401
NCBI Accession NP_000441
UniProt P16581
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Thromboxane A2 Receptor Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Phosphate buffered saline pH 7.2 (PBS), 10 mg/mL bovine serum albumin (BSA) as a stabilizer and 0.09 % sodium azide as a preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Goebeler, Roth, Meinardus-Hager, Sorg: "The contact allergens nickel chloride and cobalt chloride directly induce expression of endothelial adhesion molecules." in: Behring Institute Mitteilungen, Issue 92, pp. 191-201, 1994 (PubMed).

Goerdt, Zwadlo, Schlegel, Hagemeier, Sorg: "Characterization and expression kinetics of an endothelial cell activation antigen present in vivo only in acute inflammatory tissues." in: Experimental cell biology, Vol. 55, Issue 3, pp. 117-26, 1987 (PubMed).