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  • 产品名称：anti-CD13antibody(Alanyl(Membrane)Aminopeptidase)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD13antibody(Alanyl(Membrane)Aminopeptidase)(FITC)
详情介绍：
Immunogen Mouse intestinal APN. Spleen cells from immunised mice were fused with cells of the IR983F rat myeloma cell line.
Clone R3-63
Isotype IgG2a
Specificity This antibody recognises aminopeptidase N (APN), a cell surface protein homologous with human CD13. Clone R3-63 has been reported to block mouse APN enzyme activity. We recommend the use of SM1856A for this purpose.
Purification Affinity chromatography on Protein G
Alternative Name CD13 (ANPEP Antibody Abstract)
Background In the mouse, CD13 is a non-covalently linked homodimer of approximately 150kD subunits expressed by a variety of cells including monocytes, macrophages, dendritic cell and veiled cells.Synonyms: ANPEP, APN, Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, PEPN, gp150
Gene ID 16790
NCBI Accession NP_032512
UniProt P97449
Research Area Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells, Extracellular Matrix, Signaling
Pathways Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones
Application Notes Flow Cytometry: 1/5, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL, The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide and 1 % Bovine Serum Albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Curnis, Gasparri, Sacchi, Cattaneo, Magni, Corti: "Targeted delivery of IFNgamma to tumor vessels uncouples antitumor from counterregulatory mechanisms." in: Cancer research, Vol. 65, Issue 7, pp. 2906-13, 2005 (PubMed).

Larsen, Pedersen, Buus, Stryhn: "T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides." in: The Journal of experimental medicine, Vol. 184, Issue 1, pp. 183-9, 1996 (PubMed).

Hansen, Norén, Sjöström, Werdelin: "A mouse aminopeptidase N is a marker for antigen-presenting cells and appears to be co-expressed with major histocompatibility complex class II molecules." in: European journal of immunology, Vol. 23, Issue 9, pp. 2358-64, 1993 (PubMed).