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  • 产品名称：anti-AngiotensinIConvertingEnzyme1antibody(AngiotensinIConvertingEnzyme(Peptidy

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-AngiotensinIConvertingEnzyme1antibody(AngiotensinIConvertingEnzyme(Peptidyl-DipeptidaseA)1)(PE)
详情介绍：
Immunogen Human lung CD143 (Angiotensin converting enzyme). Spleen cells from immunised Balb/c mice were fused with cells of the mouse X63 - Ag8 - 653 myeloma cell line.
Clone 9B9
Isotype IgG1
Specificity This antibody recognises CD143, also know as Angiotensin-Converting Enzyme (ACE). This antibody recognises active ACE binding to an N-terminal domain epitope, different to that recognised by clone i2H5 (SM1656).
Purification Affinity Chromatography on Protein G.
Alternative Name ACE / CD143 (ACE Antibody Abstract)
Background CD143 exists in two forms, a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa.Synonyms: Angiotensin-converting enzyme, DCP, DCP1, Dipeptidyl carboxypeptidase I
Gene ID 1636
NCBI Accession NP_000780
UniProt P12821
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration
Application Notes Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1 mL distilled water.
Concentration 0.1 mg/mL
Buffer Contains 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody at 2-8 °C. DO NOT FREEZE!
Background publications Metzger, Bohle, Chumachenko, Danilov, Franke: "CD143 in the development of atherosclerosis." in: Atherosclerosis, Vol. 150, Issue 1, pp. 21-31, 2000 (PubMed).

Danilov, Jaspard, Churakova, Towbin, Savoie, Wei, Alhenc-Gelas: "Structure-function analysis of angiotensin I-converting enzyme using monoclonal antibodies. Selective inhibition of the amino-terminal active site." in: The Journal of biological chemistry, Vol. 269, Issue 43, pp. 26806-14, 1994 (PubMed).

Danilov, Muzykantov, Martynov, Atochina, Sakharov IYu, Trakht, Smirnov: "Lung is the target organ for a monoclonal antibody to angiotensin-converting enzyme." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 64, Issue 1, pp. 118-24, 1991 (PubMed).