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  • 产品名称：anti-Egf-LikeModuleContaining,Mucin-Like,HormoneReceptor-Like2(EMR2)antibody(PE

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-Egf-LikeModuleContaining,Mucin-Like,HormoneReceptor-Like2(EMR2)antibody(PE)
详情介绍：
Immunogen NIH-3T3 cells stably transfected with EMR2 (EGF1-5) cDNA. Spleen cells from immunised Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Clone 2A1
Isotype IgG1
Specificity This antibody recognises EMR2. Clone 2A1 specifically recognises the stalk region of EMR2.
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Alternative Name CD312 / EMR2 (EMR2 Antibody Abstract)
Background EMR2 is a member of the epidermal growth factor-seven transmembrane (EGF-TM7) family of proteins, which is closely related to CD97. EMR2, also known as CD312, is predominantly expressed on myeloid dendritic cells, monocytes and tissue macrophages. Various isoforms of EMR2 have been documented. The ligand for the largest isoform of EMR2 has recently been identified as chrondroitin sulphate, which binds to the fourth EGF-like module of EMR2.Synonyms: EGF-like module EMR2, EGF-like module-containing mucin-like hormone receptor-like 2
Gene ID 30817
NCBI Accession NP_038475
UniProt Q9UHX3
Application Notes Flow Cytometry (Neat): Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 0.25 mL distilled water.
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4, 0.09 % Sodium Azide, 1 % BSA, 5 % Sucrose
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Background publications Yona, Lin, Dri, Davies, Hayhoe, Lewis, Heinsbroek, Brown, Perretti, Hamann, Treacher, Gordon, Stacey: "Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 22, Issue 3, pp. 741-51, 2008 (PubMed).

Lin, Chang, Davies, Stacey, Harris, Gordon: "Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif." in: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31823-32, 2004 (PubMed).

Kwakkenbos, Kop, Stacey, Matmati, Gordon, Lin, Hamann: "The EGF-TM7 family: a postgenomic view." in: Immunogenetics, Vol. 55, Issue 10, pp. 655-66, 2004 (PubMed).

Stacey, Chang, Davies, Kwakkenbos, Sanderson, Hamann, Gordon, Lin: "The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans." in: Blood, Vol. 102, Issue 8, pp. 2916-24, 2003 (PubMed).

Kwakkenbos, Chang, Lin, Pouwels, de Jong, van Lier, Gordon, Hamann: "The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells." in: Journal of leukocyte biology, Vol. 71, Issue 5, pp. 854-62, 2002 (PubMed).