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  • 产品名称：anti-MacrophageScavengerReceptor1antibody(MSR1)(PE)

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简单介绍：
anti-MacrophageScavengerReceptor1antibody(MSR1)(PE)
详情介绍：
Immunogen RAW264 cell line. Spleen cells from immunised AO rats were fused with cells of the Y3 rat myeloma cell line.
Clone 2F8
Isotype IgG2b
Specificity This antibody recognises the murine scavenger receptor class A (SRA), type I and II, also known as CD204. Clone 2F8 inhibits the uptake of acetylated low-density lipoproteins and also inhibits divalent cation independent adhesion. Recent research shows that clone 2F8 recognises an epitope within SRA that is polymorphic in the SRA from C57BL/6 mice. Clone 2F8 is therefore unsuitable for use with the C57BL/6 mouse strain.
Purification Affinity chromatography on Protein G
Alternative Name CD204 (MSR1 Antibody Abstract)
Background CD204 is expressed by tissue macrophages and functions both as an endocytic receptor for lipoproteins and as an adhesion receptor for macrophages binding to ligand rich tissues e.g. atherosclerotic lesions.Synonyms: MSR1, Macrophage acetylated LDL receptor I and II, Macrophage scavenger receptor types I and II, SCARA1, Scavenger receptor class A member 1
Gene ID 20288
NCBI Accession NP_001106797
UniProt P30204
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1 mL distilled water.
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide and 1 % Bovine Serum Albumin
Preservative Sodium azide
Precaution of Use Use of sodium azide as a preservative will substantially inhibit the enzyme activity of horseradish peroxidase.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Daugherty, Whitman, Block, Rateri: "Polymorphism of class A scavenger receptors in C57BL/6 mice." in: Journal of lipid research, Vol. 41, Issue 10, pp. 1568-77, 2001 (PubMed).

Hughes, Fraser, Gordon: "Murine macrophage scavenger receptor: in vivo expression and function as receptor for macrophage adhesion in lymphoid and non-lymphoid organs." in: European journal of immunology, Vol. 25, Issue 2, pp. 466-73, 1995 (PubMed).

Bell, Lopez-Gonzalez, Lawson, Hughes, Fraser, Gordon, Perry: "Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS." in: Journal of neurocytology, Vol. 23, Issue 10, pp. 605-13, 1995 (PubMed).

Hughes, Fraser, Gordon: "Murine M phi scavenger receptor: adhesion function and expression." in: Immunology letters, Vol. 43, Issue 1-2, pp. 7-14, 1995 (PubMed).

de Villiers, Fraser, Hughes, Doyle, Gordon: "Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function." in: The Journal of experimental medicine, Vol. 180, Issue 2, pp. 705-9, 1994 (PubMed).

Fraser, Hughes, Gordon: "Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor." in: Nature, Vol. 364, Issue 6435, pp. 343-6, 1993 (PubMed).