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  • 产品名称：anti-EGFRantibody(EpidermalGrowthFactorReceptor)(ExtracellularDomain)(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-EGFRantibody(EpidermalGrowthFactorReceptor)(ExtracellularDomain)(PE)
详情介绍：
Immunogen Extracellular domain of human EGF-receptor from head and neck carcinoma.
Clone ICR10
Isotype IgG2a
Specificity This antibody recognises the epidermal growth factor receptor (EGFR). This antibody binds to epitope B from EGFR (1, 2).Aff. Const.:6.7 x 10e-9 M
Purification Affinity chromatography on Protein G
Alternative Name EGFR / ERBB1 (EGFR Antibody Abstract)
Background EGFR is over expressed in a high proportion of breast cancer cells and in a range of other carcinomas. High level expression of EGFR is often associated with advanced disease and poor prognosis.Synonyms: EGF Receptor, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, c-ErbB-1, erbB-1
Gene ID 1956
NCBI Accession NP_005219
UniProt P00533
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation
Application Notes Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1.0 mL distilled water
Buffer PBS containing 1 % BSA and 5 % Bovine Serum Albumin
Preservative Sodium azide
Precaution of Use Use of sodium azide as a preservative will substantially inhibit the enzyme activity of horseradish peroxidase.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Modjtahedi, Dean: "The receptor for EGF and its ligands - expression, prognostic value and target for therapy in cancer (review)." in: International journal of oncology, Vol. 4, Issue 2, pp. 277-96, 2011 (PubMed).