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  • 产品名称：anti-CD5antibody(CD5Molecule)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD5antibody(CD5Molecule)(FITC)
详情介绍：
Clone MCD5
Isotype IgG2b
Specificity MCD5 recognizes a 67 kDa antigen on human T cells. Other species not tested.
Purification Affinity chromatography
Alternative Name CD5 (CD5 Antibody Abstract)
Background CD5 appears to be a relatively late marker during B cell differentiation. CD5 expression is thought to be absent on surface Ig negative B-lineage cells but appears on IgM+ cells in both fetal liver and bone marrow. It co-precipitates with the T cell receptor and, in particular with Lck. A role for CD5 in signal transduction is postulated based on stimulatory effects of CD5 monoclonal antibodies. CD5 antigen is phosphorylated on tyrosine residues on T cell activation. There is evidence that CD5 plays a role in thymocyte selection, as well as a role in cell-cell recognition. Recently CD5 on B cells has been shown to be an endogenous ligand selective for B-cell surface IgFR (framework region) sequences. Interaction of surface Ig with CD5, other endogenous antigens or (in mucosal sites) exogenous superantigens can provide B cells with continual stimulation and might prevent their elimination from the immune system. In addition, B cell superantigens, e.g. Staphylococcus aureus Cowan strain 1, may contribute to the pathogenesis of autoimmune diseases and malignancies.Synonyms: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5
Gene ID 921
NCBI Accession NP_055022
UniProt P06127
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. This product is photosensitive and should be protected from light.
Supplier Images
image for anti-CD5 antibody (CD5 Molecule) (FITC) (ABIN1106440) anti-CD5 Molecule (CD5) antibody (FITC)
Background publications Pospisil, Mage: "CD5 and other superantigens as 'ticklers' of the B-cell receptor." in: Immunology today, Vol. 19, Issue 3, pp. 106-8, 1998 (PubMed).

Tarakhovsky, Kanner, Hombach, Ledbetter, Müller, Killeen, Rajewsky: "A role for CD5 in TCR-mediated signal transduction and thymocyte selection." in: Science (New York, N.Y.), Vol. 269, Issue 5223, pp. 535-7, 1995 (PubMed).

Muthukkumar, Bondada: "Involvement of CD5 in Th1 and Th2 contact-mediated rescue of anti-mu and ionomycin induced growth inhibition in a B cell lymphoma." in: International immunology, Vol. 7, Issue 2, pp. 305-15, 1995 (PubMed).

Raab, Yamamoto, Rudd: "The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck." in: Molecular and cellular biology, Vol. 14, Issue 5, pp. 2862-70, 1994 (PubMed).

van Rood: "HLA and I." in: Annual review of immunology, Vol. 11, pp. 1-28, 1993 (PubMed).

Huang, Jones, Strominger, Herzenberg: "Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 1, pp. 204-8, 1987 (PubMed).