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  • 产品名称：anti-SELPantibody(SelectinP(GranuleMembraneProtein140kDa,AntigenCD62))(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-SELPantibody(SelectinP(GranuleMembraneProtein140kDa,AntigenCD62))(FITC)
详情介绍：
Immunogen Human platelet membrane glycoproteins.
Clone AK-6
Isotype IgG1
Specificity This antibody reacts with a 140 kDa antigen expressed on activated platelets and also on endothelial cells both of blood and lymph vessels.
Cross-Reactivity (Details) Species reactivity (tested):Human and Rhesus Monkey.
Purification Affinity Chromatography on Protein G
Alternative Name CD62P / P-Selectin (SELP Antibody Abstract)
Background CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.Synonyms: CD62 antigen-like family member P, GMP-140, GMRP, GRMP, Granule membrane protein 140, LECAM3, Leukocyte-endothelial cell adhesion molecule 3, PADGEM, SELP
Gene ID 6403
NCBI Accession NP_002996
UniProt P16109
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.09 % Sodium Azide, 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Kornerup, Salmon, Pitchford, Liu, Page: "Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 109, Issue 3, pp. 758-67, 2010 (PubMed).

Knipe, Meli, Hewlett, Bierings, Dempster, Skehel, Hannah, Carter: "A revised model for the secretion of tPA and cytokines from cultured endothelial cells." in: Blood, Vol. 116, Issue 12, pp. 2183-91, 2010 (PubMed).

van Nispen tot Pannerden, de Haas, Geerts, Posthuma, van Dijk, Heijnen: "The platelet interior revisited: electron tomography reveals tubular alpha-granule subtypes." in: Blood, Vol. 116, Issue 7, pp. 1147-56, 2010 (PubMed).

Dalli, Norling, Renshaw, Cooper, Leung, Perretti: "Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles." in: Blood, Vol. 112, Issue 6, pp. 2512-9, 2008 (PubMed).

Norling, Sampaio, Cooper, Perretti: "Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 22, Issue 3, pp. 682-90, 2008 (PubMed).

Wassmer, Taylor, Maclennan, Kanjala, Mukaka, Molyneux, Grau: "Platelet-induced clumping of Plasmodium falciparum-infected erythrocytes from Malawian patients with cerebral malaria-possible modulation in vivo by thrombocytopenia." in: The Journal of infectious diseases, Vol. 197, Issue 1, pp. 72-8, 2008 (PubMed).

Turner, Hadley: "The role of P-selectin in the immune destruction of platelets." in: British journal of haematology, Vol. 121, Issue 4, pp. 623-31, 2003 (PubMed).

Théorêt, Bienvenu, Kumar, Merhi: "P-selectin antagonism with recombinant p-selectin glycoprotein ligand-1 (rPSGL-Ig) inhibits circulating activated platelet binding to neutrophils induced by damaged arterial surfaces." in: The Journal of pharmacology and experimental therapeutics, Vol. 298, Issue 2, pp. 658-64, 2001 (PubMed).

Sopper, Stahl-Hennig, Demuth, Johnston, Dörries, ter Meulen: "Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of rhesus monkeys." in: Cytometry, Vol. 29, Issue 4, pp. 351-62, 1998 (PubMed).

Bevilacqua, Nelson: "Selectins." in: The Journal of clinical investigation, Vol. 91, Issue 2, pp. 379-87, 1993 (PubMed).

Dunlop, Skinner, Bendall, Favaloro, Castaldi, Gorman, Gamble, Vadas, Berndt: "Characterization of GMP-140 (P-selectin) as a circulating plasma protein." in: The Journal of experimental medicine, Vol. 175, Issue 4, pp. 1147-50, 1992 (PubMed).

Skinner, Lucas, Burns, Chesterman, Berndt: "GMP-140 binding to neutrophils is inhibited by sulfated glycans." in: The Journal of biological chemistry, Vol. 266, Issue 9, pp. 5371-4, 1991 (PubMed).

Skinner, Fournier, Andrews, Gorman, Chesterman, Berndt: "Characterization of human platelet GMP-140 as a heparin-binding protein." in: Biochemical and biophysical research communications, Vol. 164, Issue 3, pp. 1373-9, 1989 (PubMed).