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  • 产品名称：anti-TNFRSF10Cantibody(TumorNecrosisFactorReceptorSuperfamily,Member10c,DecoyWi

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-TNFRSF10Cantibody(TumorNecrosisFactorReceptorSuperfamily,Member10c,DecoyWithoutAnIntracellularDomain)(AA1-280)(FITC)
详情介绍：
Immunogen TRAIL-R3 (aa 1-280) - hIgGhc fusion protein.
Clone TRAIL-R3-02
Isotype IgG1
Specificity The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Characteristics Synonyms: Decoy receptor 1, TNFRSF10C, DCR1, LIT, TRID, TRAIL receptor 3, TRAIL-R3, Tumor necrosisfactor receptor superfamily member 10C, Decoy TRAIL receptor without death domain,TNF-related apoptosis-inducing ligand receptor 3, Trail receptor without an intracellulardomain, Lymphocyte inhibitor of TRAIL, Antagonist decoy receptor for TRAIL/Apo-2L
Alternative Name CD263 / TRAILR3 (TNFRSF10C Antibody Abstract)
Background TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).Synonyms: Antagonist decoy receptor for TRAIL/Apo-2L, DCR1, Decoy TRAIL receptor without death domain, Decoy receptor 1, LIT, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TNFRSF10C, TRAIL receptor 3, TRAIL-R3, TRID, Trail receptor without an intracellular domain, Tumor necrosis factor receptor superfamily member 10C
Gene ID 8794
UniProt O14798
Research Area Signaling, Apoptosis/Necrosis
Pathways Apoptosis
Application Notes Flow Cytometry: 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS containing 15 mM Sdium Azide as preservative and 0.2 % (w/v) high-grade (Protease free) BSA as a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid prolonged exposure to light.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Deligezer, Dalay: "Expression of the TRAIL receptors in blood mononuclear cells in leukemia." in: Pathology oncology research : POR, Vol. 13, Issue 4, pp. 290-4, 2007 (PubMed).

Falschlehner, Emmerich, Gerlach, Walczak: "TRAIL signalling: decisions between life and death." in: The international journal of biochemistry & cell biology, Vol. 39, Issue 7-8, pp. 1462-75, 2007 (PubMed).

Mérino, Lalaoui, Morizot, Schneider, Solary, Micheau: "Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2." in: Molecular and cellular biology, Vol. 26, Issue 19, pp. 7046-55, 2006 (PubMed).

Clancy, Mruk, Archer, Woelfel, Mongkolsapaya, Screaton, Lenardo, Chan: "Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 50, pp. 18099-104, 2005 (PubMed).

Sanlioglu, Dirice, Aydin, Erin, Koksoy, Sanlioglu: "Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells." in: BMC cancer, Vol. 5, pp. 54, 2005 (PubMed).