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  • 产品名称：anti-CD31antibody(Platelet/endothelialCellAdhesionMolecule)(Biotin)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD31antibody(Platelet/endothelialCellAdhesionMolecule)(Biotin)
详情介绍：
Clone WM59
Isotype IgG1
Purification Affinity chromatography on Protein G.
Alternative Name CD31 / PECAM1 (PECAM1 Antibody Abstract)
Background CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed on the surface of endothelial cells, and concentrated at the junction between them. It is also weakly expressed on many peripheral lymphoid cells and platelets. CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas). CD31 is a 130kD glycoprotein expressed by platelets, endothelial cells, granulocytes and some lymphocytesSynonyms: End °CAM, GPIIA', PECAM-1, Platelet endothelial cell adhesion molecule
Gene ID 9606
UniProt P16284
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of Actin Filament Polymerization
Application Notes Flow Cytometry: Use 10 μL of neat-1/10 diluted antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-CD31 antibody (Platelet/endothelial Cell Adhesion Molecule) (Biotin) (ABIN119125) Staining of human peripheral blood platelets with MOUSE ANTI HUMAN CD31:BIOTIN (ABIN1...
Background publications Urquhart, Rosignoli, Cooper, Motterlini, Perretti: "Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow." in: The Journal of pharmacology and experimental therapeutics, Vol. 321, Issue 2, pp. 656-62, 2007 (PubMed).

Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000 (PubMed).

DeLisser, Newman, Albelda: "Molecular and functional aspects of PECAM-1/CD31." in: Immunology today, Vol. 15, Issue 10, pp. 490-5, 1994 (PubMed).

Stockinger, Gadd, Eher, Majdic, Schreiber, Kasinrerk, Strass, Schnabl, Knapp: "Molecular characterization and functional analysis of the leukocyte surface protein CD31." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 11, pp. 3889-97, 1991 (PubMed).

Cabañas, Sanchez-Madrid, Bellon, Figdor, Te Velde, Fernandez, Acevedo, Bernabeu: "Characterization of a novel myeloid antigen regulated during differentiation of monocytic cells." in: European journal of immunology, Vol. 19, Issue 8, pp. 1373-8, 1989 (PubMed).