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  • 产品名称：anti-TNFRSF10Dantibody(TumorNecrosisFactorReceptorSuperfamily,Member10d,Decoywi

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-TNFRSF10Dantibody(TumorNecrosisFactorReceptorSuperfamily,Member10d,DecoywithTruncatedDeathDomain)(AA1-210)(FITC)
详情介绍：
Immunogen TRAIL-R4 (aa 1-210) - hIgGhc fusion protein
Clone TRAIL-R4-01
Isotype IgG1
Specificity The antibody TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Characteristics Synonyms: TNFRSF10D, DCR2, TRAIL-R4, TRUNDD, Decoy receptor 2, TRAIL receptor 4, Tumor necrosisfactor receptor superfamily member 10D, TNF-related apoptosis-inducing ligand receptor 4,TRAIL receptor with a truncated death domain
Alternative Name CD264 / TRAILR4 (TNFRSF10D Antibody Abstract)
Background TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).Synonyms: DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRAIL-R4, TRUNDD, Tumor necrosis factor receptor superfamily member 10D
Gene ID 8793
UniProt Q9UBN6
Research Area Signaling, Apoptosis/Necrosis
Pathways Apoptosis
Application Notes Flow Cytometry: 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS containing 15 mM Sdium Azide as preservative and 0.2 % (w/v) high-grade (Protease free) BSA as a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid prolonged exposure to light.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Deligezer, Dalay: "Expression of the TRAIL receptors in blood mononuclear cells in leukemia." in: Pathology oncology research : POR, Vol. 13, Issue 4, pp. 290-4, 2007 (PubMed).

Falschlehner, Emmerich, Gerlach, Walczak: "TRAIL signalling: decisions between life and death." in: The international journal of biochemistry & cell biology, Vol. 39, Issue 7-8, pp. 1462-75, 2007 (PubMed).

Mérino, Lalaoui, Morizot, Schneider, Solary, Micheau: "Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2." in: Molecular and cellular biology, Vol. 26, Issue 19, pp. 7046-55, 2006 (PubMed).

Clancy, Mruk, Archer, Woelfel, Mongkolsapaya, Screaton, Lenardo, Chan: "Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 50, pp. 18099-104, 2005 (PubMed).

Sanlioglu, Dirice, Aydin, Erin, Koksoy, Sanlioglu: "Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells." in: BMC cancer, Vol. 5, pp. 54, 2005 (PubMed).