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  • 产品名称：anti-ITGAEantibody(Integrin,alphaE(AntigenCD103,HumanMucosalLymphocyteAntigen1,

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-ITGAEantibody(Integrin,alphaE(AntigenCD103,HumanMucosalLymphocyteAntigen1,alphaPolypeptide))(FITC)
详情介绍：
Immunogen Hairy cell leukaemia cells. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NSO myeloma cell line.
Clone LF61
Isotype IgG1
Specificity This antibody recognises the Human CD103 cell surface antigen. Other species not tested.
Purification Affinity Chromatography on Protein A
Alternative Name CD103 (ITGAE Antibody Abstract)
Background CD103/Integrin alpha E is a new member of the integrin series of adhesion molecules containing the beta7 subunit. This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20 % of lamina propria T cells. Expression of CD103 is more restricted outside these mucosal organs, appearing at lower levels on T cell subsets of the lymph node, dendritic epidermis and periphery. In non-epithelial CD103+ T cells there is a bias toward expression on CD8+ cells. Integrin alpha E is a heterodimer comprising a 150 kDa alpha chain and a 120 kDa beta chain. Integrin alpha E is expressed by approximately 1 % of peripheral blood lymphocytes, activated T lymphocytes and by hairy cell leukaemia cells. The antigen is also expressed by intraepithelial lymphocytes. It has recently been shown to be identical to the alpha E integrin.Synonyms: HML-1 antigen, ITGAE, Integrin alpha-E, Integrin alpha-IEL, Mucosal lymphocyte 1 antigen
Gene ID 3682
NCBI Accession NP_002199
UniProt P38570
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: Use 5 μL of neat-1/10 diluted antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.09 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Ling, Dulphy, Bahl, Salio, Maskell, Piris, Warren, George, Mortensen, Cerundolo: "Modulation of CD103 expression on human colon carcinoma-specific CTL." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 5, pp. 2908-15, 2007 (PubMed).

Falini, Pileri, Flenghi, Liberati, Stein, Gerli, Minelli, Martelli, Lauria, Poggi: "Selection of a panel of monoclonal antibodies for monitoring residual disease in peripheral blood and bone marrow of interferon-treated hairy cell leukaemia patients." in: British journal of haematology, Vol. 76, Issue 4, pp. 460-8, 1991 (PubMed).

Flenghi, Spinozzi, Stein, Krushwitz, Pileri, Falini: "LF61: a new monoclonal antibody directed against a trimeric molecule (150 kDa, 125 kDa, 105 kDa) associated with hairy cell leukaemia." in: British journal of haematology, Vol. 76, Issue 4, pp. 451-9, 1991 (PubMed).