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  • 产品名称：anti-CD38antibody(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD38antibody(FITC)
详情介绍：
Clone NIMR-5
Isotype IgG2a
Specificity This antibody is specific to CD38 (Mr. 42-46 kDa). Monoclonal antibodies to CD38 have been shown to induce B- and T-cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis. (Ref.1-8)
Characteristics Synonyms: cADPr hydrolase 1, T10, ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1
Background Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing Nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells, and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRalphabeta+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages.Synonyms: ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1, T10, cADPr hydrolase 1
Gene ID 12494
UniProt P56528
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: < / = 1 μg/10^6 cells. (Ref.1-8)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CD38 antibody (FITC) (ABIN370931) anti-CD38 antibody (FITC)
Background publications Lund, Solvason, Grimaldi, Parkhouse, Howard: "Murine CD38: an immunoregulatory ectoenzyme." in: Immunology today, Vol. 16, Issue 10, pp. 469-73, 1995 (PubMed).

Kirkham, Santos-Argumedo, Harnett, Parkhouse: "Murine B-cell activation via CD38 and protein tyrosine phosphorylation." in: Immunology, Vol. 83, Issue 4, pp. 513-6, 1995 (PubMed).

Kumagai, Coustan-Smith, Murray, Silvennoinen, Murti, Evans, Malavasi, Campana: "Ligation of CD38 suppresses human B lymphopoiesis." in: The Journal of experimental medicine, Vol. 181, Issue 3, pp. 1101-10, 1995 (PubMed).

Bean, Godfrey, Ferlin, Santos-Argumedo, Parkhouse, Howard, Zlotnik: "CD38 expression on mouse T cells: CD38 defines functionally distinct subsets of alpha beta TCR+CD4-CD8- thymocytes." in: International immunology, Vol. 7, Issue 2, pp. 213-21, 1995 (PubMed).

Harada, Santos-Argumedo, Chang, Grimaldi, Lund, Brannan, Copeland, Jenkins, Heath, Parkhouse: "Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 6, pp. 3111-8, 1993 (PubMed).

Santos-Argumedo, Teixeira, Preece, Kirkham, Parkhouse: "A B lymphocyte surface molecule mediating activation and protection from apoptosis via calcium channels." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 6, pp. 3119-30, 1993 (PubMed).

Howard, Grimaldi, Bazan, Lund, Santos-Argumedo, Parkhouse, Walseth, Lee: "Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38." in: Science (New York, N.Y.), Vol. 262, Issue 5136, pp. 1056-9, 1993 (PubMed).