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  • 产品名称：anti-CD276antibody(CD276Molecule)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD276antibody(CD276Molecule)(FITC)
详情介绍：
Clone MIH42
Isotype IgG1
Specificity This antibody detects CD276, a member of the B7 family of co-stimulatory molecules also known as B7-H3.
Characteristics Synonyms: B7 homolog 3, 4Ig-B7-H3, PSEC0249, Costimulatory molecule
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Alternative Name CD276 / B7H3 (CD276 Antibody Abstract)
Background CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.Synonyms: 4Ig-B7-H3, B7 homolog 3, Costimulatory molecule, PSEC0249
Gene ID 80381
UniProt Q5ZPR3
Application Notes Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containsSodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled bytrained staff only.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CD276 antibody (CD276 Molecule) (FITC) (ABIN317045) anti-CD276 Molecule (CD276) antibody (FITC)
Background publications Ma, Luo, Qiao, Dong, Pan, Jiang, Krissansen, Sun: "Complete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy." in: Journal of hepatology, Vol. 46, Issue 1, pp. 98-106, 2006 (PubMed).

Sun, Vale, Leung, Kanwar, Gupta, Krissansen: "Mouse B7-H3 induces antitumor immunity." in: Gene therapy, Vol. 10, Issue 20, pp. 1728-34, 2003 (PubMed).

Chapoval, Ni, Lau, Wilcox, Flies, Liu, Dong, Sica, Zhu, Tamada, Chen: "B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production." in: Nature immunology, Vol. 2, Issue 3, pp. 269-74, 2001 (PubMed).