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  • 产品名称：anti-TNFRSF18antibody(TumorNecrosisFactorReceptorSuperfamily,Member18)(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-TNFRSF18antibody(TumorNecrosisFactorReceptorSuperfamily,Member18)(PE)
详情介绍：
Immunogen NB2/6TG cells transfected with mouse GITR. Cell from immunised DA rats were fused with cells of the Y3/Ag1.2.3 myeloma cell line.
Clone YGITR765
Isotype IgG2b
Purification Affinity chromatography on Protein G
Alternative Name TNFRSF18 / GITR (TNFRSF18 Antibody Abstract)
Background GITR is a member of the tumour necrosis superfamily, which is also referred to as TNFRSF18. Mouse GITR is predominantly expressed by CD4+/CD25+ T regulatory cells and on CD4+/CD25- cells upon activation. Studies demonstrate that mouse GITR ligand (mGITRL) can bind to mGITR and neutralise the suppressive effects of CD4+CD25+ regulatory T cells. GITR signalling can also enhance the proliferation of naive and primed T cells, suggesting a key role for GITR in the regulation of T cell-mediated immunity.Synonyms: AITR, Activation-inducible TNFR family receptor, Glucocorticoid-induced TNFR-related protein, Tumor necrosis factor receptor superfamily member 18
Gene ID 8784
NCBI Accession NP_004186
UniProt Q9Y5U5
Research Area Hormones, Receptors, Growth Factors
Application Notes Flow Cytometry: The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1.0 mL distilled water
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide and 1 % Bovine Serum Albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to and following reconstitution store the antibody at -20 °C.
Background publications Cobbold, Castejon, Adams, Zelenika, Graca, Humm, Waldmann: "Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 10, pp. 6003-10, 2004 (PubMed).