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  • 产品名称：anti-VCAM1antibody(VascularCellAdhesionMolecule1)(Biotin)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-VCAM1antibody(VascularCellAdhesionMolecule1)(Biotin)
详情介绍：
Immunogen Full length protein
Clone 1G11B1
Isotype IgG1
Specificity This antibody recognizes vascular cell adhesion molecule-1 (VCAM-1).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein G
Alternative Name CD106 / VCAM1 (VCAM1 Antibody Abstract)
Background VCAM-1 is a member of the immunoglobulin superfamily of adhesion molecules, which includes ICAMs, PECAM-s and MADCAM, and is involved in leukocyte-endothelial cell interactions. The immunoglobulin superfamily is a type I transmembrane protein characterized by extracellular immunoglobin domains, a transmembrane region and a cytoplasmic tail. They are essential for the development of the embryo and for immune and inflammatory responses. These transmembrane glycoproteins mediate cell interaction with, and adhesion to, other cells and the extracellular matrix. VCAM-1 contains six immunoglobulin domains of the H-type and interacts with VLA-4 expressed on leukocytes. Multiple adhesion molecules play a role in leukocyte recruitment. The process of migration of a leukocyte through the vascular endothelium consists of the following steps: leukocyte-endothelium interaction (first tethering and rolling and than adhesion) and transendothelial migration. VCAM-1 is almost not expressed under physiological conditions. However, under appropriate pro-inflammatory conditions where the endothelium is exposed to inflammatory cytokines such as tumour necrosis factor-α or IL-1b and becomes activated, VCAM-1 gene expression is rapid elevated by the vascular endothelium. There is also a soluble form of VCAM-1 which is angiogenic and chemotactic for endothelial cells. sVCAM-1 is up-regulated in several disease states (eg, myocardial infarction, type 2 diabetes mellitus, primary antiphospholipid syndrome, and rheumatoid arthritis).Synonyms: INCAM-100, L1CAM, V-CAM 1, VCAM-1, Vascular cell adhesion protein 1
Gene ID 7412
NCBI Accession NP_001069
UniProt P19320
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Carbohydrate Homeostasis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Background publications Roussel, Houle, Chan, Yao, Bérubé, Olivenstein, Martin, Huot, Hamid, Ferri, Rousseau: "IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 8, pp. 4531-7, 2010 (PubMed).

Wijbrandts, Dijkgraaf, Kraan, Vinkenoog, Smeets, Dinant, Vos, Lems, Wolbink, Sijpkens, Dijkmans, Tak: "The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium." in: Annals of the rheumatic diseases, Vol. 67, Issue 8, pp. 1139-44, 2008 (PubMed).

Dienst, Grunow, Unruh, Rabausch, Nör, Fries, Gottstein: "Specific occlusion of murine and human tumor vasculature by VCAM-1-targeted recombinant fusion proteins." in: Journal of the National Cancer Institute, Vol. 97, Issue 10, pp. 733-47, 2005 (PubMed).

Van der Vieren, Crowe, Hoekstra, Vazeux, Hoffman, Grayson, Bochner, Gallatin, Staunton: "The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 4, pp. 1984-90, 1999 (PubMed).

Thornhill, Wellicome, Mahiouz, Lanchbury, Kyan-Aung, Haskard et al.: "Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 2, pp. 592-8, 1991 (PubMed).

Poggio, Gonzalez, Krause: "Stereoscopic mechanisms in monkey visual cortex: binocular correlation and disparity selectivity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 8, Issue 12, pp. 4531-50, 1989 (PubMed).