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  • 产品名称：ColonyStimulatingFactor1(Macrophage)(CSF1)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
ColonyStimulatingFactor1(Macrophage)(CSF1)(Active)Protein
详情介绍：
Sequence EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQG HERQSEGS
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine M-NFS-60 cells is less than 1 ng/mL, corresponding to a specific activity of ＞ 1.0 x 106 IU/mg.
Purity >95 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.
Synonyms: CSF-1, MCSF, Lanimostim, ,
Molecular Weight 36.8 kDa
UniProt P09603
Pathways RTK Signaling
Restrictions For Research Use only
Format Lyophilized
Buffer 0. 2μm filtered PBS, pH 7.4
Storage -20 °C