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  • 产品名称：LeukemiaInhibitoryFactor(LIF)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
LeukemiaInhibitoryFactor(LIF)(Active)Protein
详情介绍：
Sequence SPLPITPVNA TCAIRHPCHN NLMNQIRSQL AQLNGSANAL FILYYTAQGE PFPNNLDKLC GPNVTDFPPF HANGTEKAKL VELYRIVVYL GTSLGNITRD QKILNPSALS LHSKLNATAD ILRGLLSNVL CRLCSKYHVG HVDVTYGPDT SGKDVFQKKK LGCQLLGKYK QIIAVLAQAF
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent proliferation of human TF-1 cells is less than 0.1 ng/mL, corresponding to a specific activity of ＞ 1.0 x 107 IU/mg.
Purity >98?% as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Synonyms: LIF, D factor, Melanoma-derived LPL inhibitor, MLPLI, Emfilermin
Molecular Weight 19.7 kDa
UniProt P15018
Pathways JAK-STAT Signaling, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Stem Cell Maintenance, Growth Factor Binding
Restrictions For Research Use only
Format Lyophilized
Buffer PBS,?pH 7.4
Storage -20 °C