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  • 产品名称：Interleukin1ReceptorAntagonist(IL1RN)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
Interleukin1ReceptorAntagonist(IL1RN)(Active)Protein
详情介绍：
Sequence RPSGRKSSKM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNV NLEEKIDVVP IEPHALFLGI HGGKMCLSCV KSGDETRLQL EAVNITDLSE NRKQDKRFAF IRSDSGPTTS FESAACPGWF LCTAMEADQP VSLTNMPDEG VMVTKFYFQE DE
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 40 ng/mL, corresponding to a specific activity of ＞ 2.5 x 104 IU/mg in the presence of 50 pg/mL rHuI
Purity >96 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2, however, the physiological relevance of the latter association is unsure. {ECO:0000269|PubMed:7775431}.
Synonyms: IL-1RN, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra
Molecular Weight 17.1 kDa
UniProt P18510
Pathways NF-kappaB Signaling, Hormone Transport
Restrictions For Research Use only
Format Lyophilized
Buffer PBS, pH 7.4
Storage -20 °C