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  • 产品名称：Cysteine-Rich,AngiogenicInducer,61(CYR61)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
Cysteine-Rich,AngiogenicInducer,61(CYR61)(Active)Protein
详情介绍：
Sequence TCPAACHCPL EAPKCAPGVG LVRDGCGCCK VCAKQLNEDC SKTQPCDHTK GLECNFGASS TALKGICRAQ SEGRPCEYNS RIYQNGESFQ PNCKHQCTCI DGAVGCIPLC PQELSLPNLG CPNPRLVKVT GQCCEEWVCD EDSIKDPMED QDGLLGKELG FDASEVELTR NNELIAVGKG SSLKRLPVFG MEPRILYNPL QGQKCIVQTT SWSQCSKTCG TGISTRVTND NPECRLVKET RICEVRPCGQ PVYSSLKKGK KCSKTKKSPE PVRFTYAGCL SVKKYRPKYC GSCVDGRCCT PQLTRTVKMR FRCEDGETFS KNVMMIQSCK CNYNCPHANE AAFPFYRLFN DIHKFRD
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/3T3 cells is less than 3.0 μg/mL, corresponding to a specific activity of ＞ 330 IU/mg.
Purity >95?% as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.
Synonyms: CCN family member 1, Insulin-like growth factor-binding protein 10, IBP-10, IGF-binding protein 10, IGFBP-10
Molecular Weight 39.4 kDa
UniProt O00622
Research Area Hormones, Neurology
Pathways Positive Regulation of Endopeptidase Activity, Growth Factor Binding
Restrictions For Research Use only
Format Lyophilized
Buffer citrate buffer solution, 300 mM NaCl,?pH 3.0
Storage -20 °C