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  • 产品名称：Insulin-LikeGrowthFactorBindingProtein3(IGFBP3)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
Insulin-LikeGrowthFactorBindingProtein3(IGFBP3)(Active)Protein
详情介绍：
Sequence GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inhibiting IGF-II induced proliferation of serum free human MCF-7 cells is less than 200 ng/mL, corresponding to a specific activity of ＞ 5.0 x 103 IU/mg in the presence of 15
Purity >98 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. {ECO:0000269|PubMed:20353938}.
Synonyms: IBP-3, IGFBP-3
Molecular Weight 28.8 kDa
UniProt P17936
Research Area Cardiovascular, Atherosclerosis, Angiogenesis, Apoptosis/Necrosis, Hormones, Diabetes, Metabolism, Growth Factors
Pathways Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
Restrictions For Research Use only
Format Lyophilized
Buffer PBS, pH 7.4
Storage -20 °C