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  • 产品名称：Insulin-LikeGrowthFactorBindingProtein5(IGFBP5)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
Insulin-LikeGrowthFactorBindingProtein5(IGFBP5)(Active)Protein
详情介绍：
Sequence LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 cells is less than 0.4 μg/mL, corresponding to a specific activity of ＞ 2500 IU/mg in the presence of 15 ng/mL of r
Purity >96?% as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Synonyms: IBP-5, IGFBP-5
Molecular Weight 28.6 kDa
UniProt P24593
Research Area Signaling, Diabetes, Metabolism, Growth Factors
Pathways WNT Signaling, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
Restrictions For Research Use only
Format Lyophilized
Buffer PBS,?pH 7.0
Storage -20 °C