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  • 产品名称：Lymphotoxin-alpha(LTA)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
Lymphotoxin-alpha(LTA)(Active)Protein
详情介绍：
Sequence LPGVGLTPSA AQTARQHPKM HLAHSTLKPA AHLIGDPSKQ NSLLWRANTD RAFLQDGFSL SNNSLLVPTS GIYFVYSQVV FSGKAYSPKA TSSPLYLAHE VQLFSSQYPF HVPLLSSQKM VYPGLQEPWL HSMYHGAAFQ LTQGDQLSTH TDGIPHLVLS PSTVFFGAFA L
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 5 pg/mL, corresponding to a specific activity of ＞ 2.0 x 108 IU/mg in the presence of actinomycin D.
Purity >96 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Synonyms: LT-alpha, Tumor necrosis factor ligand superfamily member 1
Molecular Weight 18.7 kDa
UniProt P01374
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Restrictions For Research Use only
Format Lyophilized
Buffer PBS, pH 7.4, with 0.02 % Tween-20
Storage -20 °C