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  • 产品名称：anti-ProgesteroneReceptorantibody(PGR)

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  • 产品厂商：SXBIO
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简单介绍：
anti-ProgesteroneReceptorantibody(PGR)
详情介绍：
Isotype IgG
Purification Affinity purification
Alternative Name PGR (PGR Antibody Abstract)
Background Human progesterone receptor (PR) is expressed as two forms: the full length PR B and the short form PR A. PR A lacks the first 164 amino acid residues of PR . Both PR A and PR B are ligand activated, but differ in their relative ability to activate target gene transcription. The activity of PR is regulated by phosphorylation, at least seven serine residues are phosphorylated in its amino-terminal domain. Three sites (Ser81, Ser102, and Ser162) are unique to full length PR B, while other sites (Ser190, Ser294, Ser345, and Ser400) are shared by both isoforms. Phosphorylation of PR B at Ser190 (equivalent to Ser26 of PR A) is catalyzed by CDK2. Mutation of Ser190 results in decreased activity of PR, suggesting that the phosphorylation at Ser190 may be critical to its biological function.
Synonyms: PGR, NR3C3, PR
Pathways Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration
Application Notes WB: 1:500-1:2000, IHC: 1:50-1:200
Optimal working concentration should be determinde by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 52 % glycerol, pH7.3.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles.
Storage -20 °C/-80 °C
Storage Comment Store at -20 °C or -80 °C.