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  • 产品名称：SecretedProtein,Acidic,Cysteine-Rich(Osteonectin)(SPARC)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
SecretedProtein,Acidic,Cysteine-Rich(Osteonectin)(SPARC)(Active)Protein
详情介绍：
Sequence APQQEALPDE TEVVEETVAE VTEVSVGANP VQVEVGEFDD GAEETEEEVV AENPCQNHHC KHGKVCELDE NNTPMCVCQD PTSCPAPIGE FEKVCSNDNK TFDSSCHFFA TKCTLEGTKK GHKLHLDYIG PCKYIPPCLD SELTEFPLRM RDWLKNVLVT LYERDEDNNL LTEKQKLRVK KIHENEKRLE AGDHPVELLA RDFEKNYNMY IFPVHWQFGQ LDQHPIDGYL SHTELAPLRA PLIPMEHCTT RFFETCDLDN DKYIALDEWA GCFGIKQKDI
Characteristics Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the cell growth of Mv1Lu mink lung epithelial cells is less than 3.0 μg/mL, corresponding to a specific activity of > 333 IU/mg.
Purity >98?% as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium s, an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Synonyms: Basement-membrane protein 40, Osteonectin, ON, Secreted protein acidic and rich in cysteine,
Molecular Weight 32.7 kDa
UniProt P09486
Research Area Lineage Markers, Extracellular Matrix, Tyrosine Kinases, Angiogenesis
Pathways Autophagy
Restrictions For Research Use only
Format Lyophilized
Buffer PBS,?pH 7.4.
Storage -20 °C