产品详情
查看大图

  • 产品名称：SonicHedgehog(SHH)(AA25-198),(Cys25Ile-Mutant)(Active)Protein

  • 产品型号：
  • 产品厂商：SXBIO
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
SonicHedgehog(SHH)(AA25-198),(Cys25Ile-Mutant)(Active)Protein
详情介绍：
Sequence Cys25 - Gly198 (Cys25Ile-Ile), with an N-terminal Met, Accession # Q62226
Characteristics Biological Activity: The ED50, as determined by inducing alkaline phosphatase production using murine C3H10T1/2 cells, is less than 300 ng/mL.
Purity >97 % as determined by SDS-PAGE.
Sterility 0.2 μm filtered
Background Relevance: Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO. {ECO:0000269|PubMed:14687547, ECO:0000269|PubMed:7736596}.
Synonyms: SHH, , Sonic hedgehog protein C-product Sonic hedgehog protein 27 kDa product,],
Molecular Weight 19.9 kDa
UniProt Q62226
Pathways Hedgehog Signaling, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
Restrictions For Research Use only
Format Lyophilized
Buffer 20 mM PB, pH 7.4, 150 mM NaCl
Storage -20 °C