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  • 产品名称：Angiopoietin2(ANGPT2)(AA19-496)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
Angiopoietin2(ANGPT2)(AA19-496)(Active)Protein
详情介绍：
Sequence Tyr19-Phe496, Accession # O15123
Characteristics Biological Activity: 200 ng/mL of rHuAng-2 will significantly induce phosphorylation of Tie-2 in human Tie-2 transfected murine C6 cells.
Purity >90 % as determined by SDS-PAGE.
Sterility 0.2 μm filtered
Background Relevance: Binds to TEK/TIE2, competing for the ANGPT1 , and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:9204896}.
Synonyms: ANG-2,
Molecular Weight 66 kDa
UniProt O15123
Pathways RTK Signaling
Restrictions For Research Use only
Format Lyophilized
Buffer 20 mM MOPS, 500 mM NaCl, 0.1 % PEG-8000, and 0.2 % CHAPS, pH 7.0
Storage -20 °C