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  • 产品名称：MetalloproteinaseInhibitor2(TIMP2)(Active)Protein

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  • 产品厂商：SXBIO
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简单介绍：
MetalloproteinaseInhibitor2(TIMP2)(Active)Protein
详情介绍：
Sequence CSCSPVHPQQ AFCNADVVIR AKAVSEKEVD SGNDIYGNPI KRIQYEIKQI KMFKGPEKDI EFIYTAPSSA VCGVSLDVGG KKEYLIAGKA EGDGKMHITL CDFIVPWDTL STTQKKSLNH RYQMGCECKI TRCPMIPCYI SSPDECLWMD WVTEKNINGH QAKFFACIKR SDGSCAWYRG AAPPKQEFLD IEDP
Characteristics Biological Activity: Fully biologically active when compared to standard. The biologically active as determined by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR- NH2.
Purity >95 % as determined by SDS-PAGE and HPLC.
Sterility 0.2 μm filtered
Background Relevance: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. {ECO:0000269|PubMed:11710594, ECO:0000269|PubMed:2554304, ECO:0000269|PubMed:2793861}.
Synonyms: CSC-21K, TIMP-2
Molecular Weight 21.8 kDa
UniProt P16035
Research Area Cardiovascular, Atherosclerosis, Proteolysis / Ubiquitin, Angiogenesis, Extracellular Matrix, Matrix Metalloproteinases, Cancer, Inflammation
Pathways cAMP Metabolic Process
Restrictions For Research Use only
Format Lyophilized
Buffer PBS, pH 7.4, with 3 % trehalose
Storage -20 °C