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  • 产品名称：anti-BIRC5antibody(BaculoviralIAPRepeat-Containing5)(AA1-140)

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  • 产品厂商：SXBIO
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简单介绍：
anti-BIRC5antibody(BaculoviralIAPRepeat-Containing5)(AA1-140)
详情介绍：
Immunogen Recombinant mouse Baculoviral IAP repeat-containing protein 5 protein(1-140aa)
Isotype IgG
Purification Caprylic Acid Ammonium Sulfate Precipitation purified
Alternative Name Baculoviral IAP Repeat-Containing Protein 5 (BIRC5 Antibody Abstract)
Background Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex, directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7.
UniProt O70201
Pathways Apoptosis, Cell Division Cycle
Restrictions For Research Use only
Format Liquid
Buffer Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C/-80 °C